The Substance
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
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Frequently asked questions about The Substance
Where can I watch The Substance?
The Substance is available to stream on HBO Max Amazon Channel, MUBI, MUBI Amazon Channel, and HBO Max in the US. Streaming availability is provided by JustWatch and can change over time.
What is The Substance about?
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Who stars in The Substance?
The Substance stars Demi Moore, Margaret Qualley, Dennis Quaid, Edward Hamilton-Clark, and Gore Abrams.
When did The Substance come out?
The Substance was released in 2024.
Ratings and streaming availability are aggregated from third-party sources; metadata from The Movie Database (TMDB), streaming data from JustWatch. This product uses the TMDB API but is not endorsed or certified by TMDB. Last updated September 2026.